BDBM26113 2,4 PDCA::cid_10365::pyridine carboxylate, 6a::pyridine-2,4-dicarboxylic acid

SMILES OC(=O)c1ccnc(c1)C(O)=O

InChI Key InChIKey=MJIVRKPEXXHNJT-UHFFFAOYSA-N

Data  9 KI  62 IC50  1 Kd

PDB links: 16 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 26113   

TargetBeta-lactamase(Aeromonas hydrophila)
Universit£

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of Aeromonas hydrophila beta lactamase CphA by competitive inhibition assayMore data for this Ligand-Target Pair
TargetBeta-lactamase(Aeromonas hydrophila)
Universit£

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of Aeromonas hydrophila beta lactamase CphA at pH 7.0More data for this Ligand-Target Pair
TargetBeta-lactamase(Aeromonas hydrophila)
Universit£

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataKi:  3.50E+4nMAssay Description:Inhibition of Aeromonas hydrophila beta lactamase CphA at pH 8.0More data for this Ligand-Target Pair
TargetBeta-lactamase(Aeromonas hydrophila)
Universit£

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataKi:  1.60E+5nMAssay Description:Inhibition of Aeromonas hydrophila beta lactamase CphA at pH 9.0More data for this Ligand-Target Pair
TargetBeta-lactamase(Aeromonas hydrophila)
Universit£

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataKi:  5.20E+5nMAssay Description:Inhibition of Aeromonas hydrophila beta lactamase CphA at pH 10.0More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataKi:  9.14E+5nMAssay Description:Inhibition of JMJD2EMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  1.50E+3nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of N-terminal His6-tagged full-length FIH (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using SMDESGLPQLTSYDCEVNAPIQG...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of KDM5B (unknown origin) expressed in Escherichia coli using H3 (1 to 21 residues) K4Me3-GGK-Biotin KDM5B Cognate Ligand/10 uM alpha-keto...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4D(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of KDM4D (unknown origin) expressed in Escherichia coli using H3 (1 to 21 residues) K9Me3-GGK-Biotin KDM4 Cognate Ligand/10 uM alpha-ketog...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of KDM4A (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assayMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant KDM5B catalytic domain (1 to 769 residues) (unknown origin)More data for this Ligand-Target Pair
TargetAspartyl/asparaginyl beta-hydroxylase(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 u...More data for this Ligand-Target Pair
TargetAspartyl/asparaginyl beta-hydroxylase(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  100nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with high 200 uM 2OG...More data for this Ligand-Target Pair
TargetAspartyl/asparaginyl beta-hydroxylase(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 u...More data for this Ligand-Target Pair
TargetAspartyl/asparaginyl beta-hydroxylase(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using high 10 uM hFX-CP as substrate mixture with 10 uM 2OG...More data for this Ligand-Target Pair
TargetRNA demethylase ALKBH5(Homo sapiens)TBA
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  9.43E+3nMAssay Description:Inhibition of ALKBH5 (unknown origin)More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of FIH (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of KDM4E (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of KDM4E (unknown origin ) incubated for 20 mins by Alphascreen assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM26113(2,4 PDCA | cid_10365 | pyridine carboxylate, 6a | ...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of recombinant KDM5B catalytic core (1 to 729 residues) (unknown origin) expressed in baculovirus infected insect cells by FDH coupled ass...More data for this Ligand-Target Pair